Some opportunities happen only once in a lifetime - like a job where you have the chance to change lives. At Alexion, people living with rare and devastating diseases are our Guiding Star. We are driven to continuously innovate and create meaningful value in all we do to help patients and families fully live their best lives. We value the uniqueness and diversity of our employees and recognize that nurturing the diverse perspectives and strengths of our people translates into innovative breakthroughs for patients.

This is what you will do:

• We are seeking a highly motivated in vivo pharmacologist to work in a dynamic preclinical environment focused on delivering clinically translatable solutions to advancing drug development inflammatory, autoimmune, and retinal disorders. The full-time role will focus on the design, development, and evaluation of lead therapeutics in nonclinical pharmacology studies and ex vivo biochemical and bioanalytical assays support. The successful candidate will contribute to development and characterization of in vivo mouse models, as well as support ex vivo protein and cellular analysis.

You will be responsible to:

• Designs, executes, and interprets experiments, with a high degree of reliability and independence
• Exercises emerging judgment to prioritize studies, based on Project impact
• Performs basic statistical analysis of experimental data, where appropriate
• Independently conducts own experimental troubleshooting on a routine basis
• Prepares lucid protocols and written study reports
• Surveys relevant scientific literature to maintain awareness of issues and trends within the field
• Present studies effectively at internal Group/Department or Project Team research meetings
• Performs other duties as assigned
• Conduct all activities in accordance with the AstraZeneca Values.

You will need to have:

• Experience in execution of well-controlled experiments to demonstrate proof-of-concept in preclinical models.
• An established and comprehensive hands-on in vivo skill set, including compound administration, anesthesia use, blood, and handling, processing, and profiling ex vivo tissue samples
• Experience with developing, executing and/or troubleshooting in vitro and ex vivo sample immunoassays
• Ability to multi-task and excellent organization to support multiple projects across platforms and disease biology/pharmacology
• Essential qualities include flexibility, adaptability and the ability to function effectively as part of an interactive team.
• Ability to perform under pressure to deliver consistent results under tight deadlines.
• Ability to work independently and in groups to solve problems.
• A commitment to embracing a diverse, inclusive, and highly collaborative team culture is essential
• The duties of this role are generally conducted in a lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours; position may require occasional on-site weekend work. In addition, employees in this role must be able, with or without an accommodation to: pass a medical evaluation; wear a respirator while maintaining a tight-fitting seal to the face.

We would prefer for you to have:

• BS 4-7 years or MS 2-4 years of experience in the development and utilization of in vivo models in an academic, medical or pharmaceutical/biotechnology environment.
• Strong verbal and written communication skills and exemplary organizational practices
• Experience using programs such as GraphPad Prism and PowerPoint for data analysis and presentation.

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Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at: www.alexion.com.

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion has taken critical steps to protect colleagues, loved ones, and patients from COVID-19 and its variants. All US-based employees must comply with Alexion's COVID-19 vaccination mandate. Alexion provides exceptions based on applicable state law as well as reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding a legally required exemption or accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.

As a leading employer in our industry, Alexion offers a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, and much more.

AstraZeneca completed its acquisition of Alexion, marking the creation of Alexion, AstraZeneca Rare Disease. If you're interested in career opportunities with AstraZeneca, click here.