Adimab is the leading provider of therapeutic antibody discovery and engineering technologies. This includes naïve discovery from synthetic libraries in yeast or B cells (mice and humans), antibody engineering and optimization, multi-specific antibody engineering, and a portfolio of proprietary CD3 antibodies licensed non-exclusively for bispecific applications. Adimab focuses solely on its partners and not on developing an internal product pipeline. Since 2009, Adimab has partnered with over 105 pharmaceutical and biotechnology companies, generating more than 475 therapeutic programs, over 60 clinical programs, and its first approved product. The Adimab technology has been transferred and implemented at Biogen, GSK, Lilly, Merck, Novo Nordisk, and Takeda. Funded discovery partners include leading pharmaceutical companies, such as Boehringer Ingelheim, Bristol Myers Squibb, Novartis, Regeneron, Sanofi, Takeda and others. Adimab has also partnered with many early-stage venture-backed companies, including Amagma, Dragonfly, iOmx, NextPoint, Pliant, Tizona, TRex Bio and others, as well as mid-size public biopharmaceutical companies such as Alector, Cullinan Oncology, Innovent, Jounce, Mersana, Scholar Rock, Surface Oncology, and others.

Adimab’s integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full-length human IgGs. Adimab offers fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most demanding standards for affinity, epitope coverage, species cross-reactivity, and developability. Adimab enables its partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.

Role

We are seeking a Principal Research Associate with experience in mammalian cell culture and protein expression to join our team. This role will support Adimab's novel antibody discovery, maturation, and production platform and closely interface with the Antibody Discovery, Protein Analytics, Molecular Core, and Computational Biology teams.

Responsibilities

• Culture, expand, and bank mammalian cell lines
• Conduct routine transient transfections of HEK and CHO cells at various scales (24-well plates to large shake flasks)
• Develop stable cell pools and clones for both secreted and membrane-bound proteins
• Periodically conduct studies to improve protein expression and yield; evaluate novel expression vectors, host cell lines, and transfection reagents, and present findings at company-wide lab meetings
• Maintain stock of host cell cultures (HEK and CHO), transfection reagents, and culture media
• Contribute to general upkeep of the cell culture lab and cell stocks

Needed upon hire

• B.S. with 1-3+ years experience
• Proficient in aseptic techniques for culturing mammalian cells in both adherent and suspension formats
• Skilled at expressing proteins in mammalian cell lines, either transiently or stably
• Knowledge of the cell and molecular biology underlying protein expression
• Ability to meticulously document and execute bench work
• Ability to work independently and demonstrates strong problem solving skills
• Curiosity and passion for science demonstrated by reading scientific literature
• Track record of communicating effectively with colleagues and supervisor
• Adaptable and productive in a fast-paced environment
• Available for some weekend work
• Industry experience and proficiency with flow cytometry preferred

Come join us!
As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We proudly promote meritocracy and reward employees who are productive, use their resources wisely, and make meaningful contributions to the team. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, and biking.

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