Scientist

Alnylam (Nasdaq: ALNY) is delivering on a bold vision to turn scientific possibility into reality, with a robust RNA interference (RNAi) therapeutics platform. As the pioneer in RNAi and the leading RNAi therapeutics company, we have always been uncompromisingly dedicated to translating the breakthrough science into transformational medicines to help as many people as possible. Long focused on rare and genetic diseases, our scientific advances are now allowing us to bring the power of RNAi therapeutics to more prevalent diseases and as a result, we are beginning to recognize the full potential of this new class of medicines.

Alnylam is committed to its journey to become a top 5 independent, global biopharma company. We are already admired and recognized for our dedication to patients, company culture that empowers people to do their best work, track record of scientific innovation, social responsibility, and commercial excellence.

Founded in 2002, and headquartered in Cambridge, Mass., Alnylam has over 1,650 employees at work across the globe. We are seeking smart, passionate, “change the world” kind of people who are ready to say, “challenge accepted” to our mission. Thanks to the commitment of every employee globally, Alnylam is proud to have been recognized as one of Fast Company’s 2021 Best Workplaces for Innovators, a Science Magazine Top Employer three years in a row (2019-2021), a Boston Globe Top Places to Work seven years in a row (2015-2021), a Great Place to Work in Asia, Brazil, the U.K., and Switzerland, Searmount’s 100 Best Companies and Best Companies for Dads, Bloomberg’s Gender Equality Index, among others.

The Sr. Scientist in Clinical Pharmacology position will support a rapidly expanding

clinical portfolio of promising RNAi therapeutics. The candidate in this position should be well

versed in PK and PD with strong ability to critically evaluate and interpret data, conduct

noncompartmental analysis, and PKPD modeling. In this role, the candidate is expected to have

a strong critical thinking ability with good oral and written communication skills.

Summary of Key Responsibilities

• Represent Clinical Pharmacology and provide PKPD support and guidance to clinical stage project teams.
• Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data
• Conduct PK/PD analyses to guide development decisions on project teams
• Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and NDA.
• Prepare appropriate documents or sections of clinical protocols, Investigator Brochures, Clinical Study Reports with respect to Clinical Pharmacology studies or data
• Preparation of abstracts and manuscripts for publication
• Closely partner with Research, Bioanalytical, Clinical functions, Regulatory, Project Management, and other R&D functions.

Qualifications

• Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with some experience in pharmaceutical industry, or M.D or Pharm.D. with equivalent experience
• Working knowledge of pharmacokinetics and modeling, PKPD principles, ADME concepts, and clinical pharmacology.
• Proficient in using Phoenix WinNonlin, R, NONMEM, or other pharmacokinetic, modeling and data visualizations software.
• Strong communication skills (verbal and written) and presentation skills are required. Excellent interpersonal skills and the ability to function in a highly matrixed team environment are essential.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.