Some opportunities happen only once in a lifetime - like a job where you have the chance to change lives. At Alexion, people living with rare and devastating diseases are our Guiding Star. We are driven to continuously innovate and create meaningful value in all we do to help patients and families fully live their best lives. We value the uniqueness and diversity of our employees and recognize that nurturing the diverse perspectives and strengths of our people translates into innovative breakthroughs for patients.

This is what you will do:

The Scientist I will join Injectable Drug Product Development group to support the development of Alexion’s biotherapeutic candidates. The Scientist I will design studies to test comparability of drug product from different batches, test compatibility of drug product with devices, and support drug product process development. This individual is expected to interact regularly with scientific staff in other Research & Development groups.

You will be responsible for:

• Executing formulation studies for Alexion pharmaceuticals’ drug candidates and commercial products.
• Supporting tech transfer activities for internal manufacturing and contract manufacturing sites.
• Conducting analytical analyses to characterize aggregates, charge variants, and subvisible particles.
• Writing internal technical reports on the executed studies.
• Assisting in preparion of external regulatory submissions for the Alexion product candidates.
• Participating in cross-functional meetings and other technical and team building activities.

You will need to have:

• Understanding of chemistry and stability of biotherapeutics (e.g. protein and oligonucleotides).
• Hands-on experience with analytical methods (e.g. LC, iCE, HIAC, microflow-imaging) and data analysis (e.g. Excel, Empower, JMP).
• Ability to independently take initiative in problem solving and finding solutions to scientific challenges with broad scope.
• Ability to lead portfolio and technology development projects and mentor others in areas of expertise.
• Ability to work in a collaborative setting and adhere to timelines.
• The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• BS in Chemistry, Biochemistry, Biophysics, Chemical engineering, or relevant field with 10+ years or MS with 6+ years of relevant experience or PhD in related area with 0-2 years of relevant experience.
• Understanding of the biotechnology products life cycle and factors impacting product stability.
• Excellent interpersonal and communication skills.
• Understanding the principle of risk assessments.
• Knowledge of cGMP and quality guidelines.

#LI-SM1

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at: www.alexion.com.

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion has taken critical steps to protect colleagues, loved ones, and patients from COVID-19 and its variants. All US-based employees must comply with Alexion's COVID-19 vaccination mandate. Alexion provides exceptions based on applicable state law as well as reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding a legally required exemption or accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.

As a leading employer in our industry, Alexion offers a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, and much more.

AstraZeneca completed its acquisition of Alexion, marking the creation of Alexion, AstraZeneca Rare Disease. If you're interested in career opportunities with AstraZeneca, click here.