Director - Protein Analytics

Full Time
Lebanon, NH 03766
Posted
Job description

We are the leading technology provider for antibody-based drug discovery, focusing solely on our partners without pursuing an internal product pipeline. Since 2009, we have partnered with over 100 pharmaceutical and biotechnology companies, generating more than 450 therapeutic programs, of which more than 55 have entered clinical trials. Our technology has been transferred and implemented at Biogen, GSK, Lilly, Merck, Novo Nordisk, and Takeda. Funded discovery partners include leading pharmaceutical companies, such as Boehringer Ingelheim, Celgene, Genentech, Gilead, Kyowa Hakko Kirin, Novartis, Roche, Sanofi, and others. We have also partnered with many early-stage venture-backed companies, including Amagma, Cullinan Oncology, Dragonfly, Pliant, Tizona, iTeos, and others, as well as mid- size public biopharmaceutical companies such as Acceleron, Alector, Five Prime, Innovent, Jounce, Mersana, Scholar Rock, Seagen, Surface Oncology, and others.

Our integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full-length human IgGs with exquisite specificity and biophysical behavior. We offer fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most demanding standards for affinity, epitope coverage, species cross-reactivity, and developability. We enable our partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.


Role

We are seeking an accomplished scientific leader with analytical expertise to lead our Protein Analytics team. Reporting to the Senior Director of Antibody Engineering and Protein Analytics, this position will oversee a team of 10+ researchers with the responsibility of rapidly and efficiently producing high quality characterization data to support both internal and external partners. The position requires a high degree of cross-functional teamwork, technical excellence, and vision to implement method development and novel scientific approaches based on literature reviews, industry trends, and internal research and development efforts.


Responsibilities

  • Provide technical expertise on, or experience managing, a variety of analytical techniques for the purpose of characterizing lead therapeutic antibody panels
  • Partner with key business stakeholders, both internal and external, to consistently provide quality data in a dynamic and time-sensitive environment
  • Contribute to scientific discussions at all levels and across all functions within the organization, as well as help troubleshoot complex technical challenges
  • Ensure the Protein Analytics Group is prepared to meet partner expectations and emerging needs
  • Identify new research directions and process improvements
  • Lead and develop a team of 10+ scientists and research associates to successfully deliver on company objectives and obligations to partners
  • Create a team-oriented, empowered group that views quality and service as top objectives while fostering an innovative environment that welcomes diverging opinions and nurtures new ideas
  • Communicate honestly and directly. When necessary, align cross-functional stakeholders around common goals through effective communication, organizational skills, and attention to detail
  • Professionally represent Adimab to customers and during business development opportunities

Needed upon hire

  • Ph.D. and 5-10 years of leadership experience in a research and development role focused on protein analytics, preferably with antibodies
  • Deep knowledge of therapeutic antibody characterization, from lead panel characterization to pre-clinical candidate selection, and the analytical techniques commonly used therein
  • Strong understanding of protein chemistry, particularly with respect to developability characteristics (e.g. aggregation, polyspecificity, posttranslational modifications)
  • Direct experience with or experience managing a wide-variety of analytical assays and techniques, such as BLI, SPR, HIC, aSEC, SDS-PAGE, LC/MS, DSF, DSC, DLS, CZE, cIEF, AC-SINS, ELISA, and protein conjugation
  • Strong publication record, peer reviewed or patents
  • Comfortable in a fast-paced environment dealing with multiple overlapping projects and time-sensitive workflows
  • Ability to set and drive big picture strategy while also having the capability to provide technical guidance to the team
  • Ability to recruit, inspire, and motivate a research team to work together as a cohesive and productive group
  • Demonstrated ability to evaluate, interpret, and present complex scientific data
  • Decisive, makes tough calls quickly when circumstances require it
  • Honest and ethical leader who gives credit where it is due
  • Approach work with a no-task-too-small mentality, hardworking and leads by example

Come join us!
As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We proudly promote meritocracy and reward employees who are productive, use their resources wisely, and make meaningful contributions to the team. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, kayaking, and biking.

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