Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team. While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive. We believe engaging on a day-to-day basis, in person, builds solid and lasting relationships, and contributes positively to our culture and innovation. From the heart of our stunning Carlsbad campus, we aim to provide a central connection point for all our employees. These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow. Join us and experience our unique culture while you develop and expand your career.

POSTDOCTORAL FELLOW – BIOLOGY

SUMMARY:

We are seeking a motivated and outstanding individual to join our CSO/ION-ARPA research and early discovery group as a Postdoctoral Fellow. The selected candidate will work within an interactive and innovative research team to explore the use of oligonucleotides to modulate nucleic acid structures as potential therapeutics. To be successful in this role will require creative thinking. Also, the ability to work independently to conceptualize, implement, and meticulously carry out experiments. The successful candidate must also have a desire to learn the skills they do not possess (with support) to make the most of the opportunity.

This postdoctoral position will provide the candidate with a well-resourced industry environment where they can accelerate the pace of their science and produce original research for high impact publications. The postdoc will gain extensive experience in oligonucleotide drug discovery, in vitro biochemical/molecular assays, cellular disease modeling, and functional genomics. This position will be highly interdisciplinary and require close collaboration with various other departments at Ionis, such as Medicinal Chemistry.

RESPONSIBILITIES:

The postdoc will be working with a group of biologists and chemists to:

• Design and execute in vitro biochemical/molecular biology/cell-based experiments
• Analyze and interpret results, and present at internal meetings and scientific conferences
• Writing original research manuscripts for scientific publication(s)

REQUIREMENTS:

• A Ph.D. degree in the life sciences (ex: biochemistry/molecular biology, biophysics, chemical biology, etc.) or D. degree
• Strong research track record as demonstrated by quality publications or patents
• Experience and ability to develop plate-based assays in vitro (ex: fluorescence, chemiluminescence)
• Essential laboratory skills including molecular biology, nucleic acid biochemistry, DNA/RNA, and protein analysis (ex: qPCR, ddPCR), tissue culture, and fluorescence microscopy
• Knowledge and experience with functional genomics techniques (ex: RNA-seq, ChIP-seq) and programming in R/Python or similar object-oriented programming is a strong plus
• The successful candidate must be a fast learner with strong organizational, written, and verbal skills, and possess the ability to work both independently and as part of a multidisciplinary team
• Please include a CV, cover letter, and list of three references in your application

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded

The pay scale for this position is $74K to $82K

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.