Job description
Job Summary:
GentiBio is seeking a Scientist to join our Platform Engineering group and develop novel cell therapies for autoimmune diseases. Reporting to the Senior Director leading the Platform Engineering group, this individual will develop and validate gene editing strategies across multiple programs. This role offers exposure to cutting-edge molecular techniques, an organizational and company build, leadership, and an ample opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy.
Responsibilities:
- Foster the culture of seeking and giving help, inclusion, authenticity, and fun
- Work across Platform Engineering and Translational Sciences teams to lead the development and validation of gene editing strategies
- Develop and execute NGS-based assays for on- and off-target assessments, including DNA/RNA extractions and NGS library preparation
- Design single cell ddPCR assays to measure chromosomal translocation activity
- Oversee CRO activities related to NGS sequencing and analysis
- Devise and execute new experimental protocols, coordinate acquisition of study materials, and ensure rigorous data analysis and interpretation
- Work independently to support multiple research initiatives and projects, while also maintaining regular communication with team members to ensure alignment with team, project, and company goals
- Maintain accurate and detailed laboratory records of all experiments performed ensuring that lab notebooks are signed weekly
- Stay abreast of relevant literature and act as a resource for the team
Qualifications and Education Requirements
- Ph.D. in a relevant scientific discipline with 0-2 years of relevant experience
- Background in molecular biology and experience with one or more NGS technologies (e.g., RNA-seq, Amp-seq, rhAmp-seq)
- Experience with viral and/or non-viral genome engineering techniques using ZFNs, TALENs, or CRISPR/Cas
- Hands on experience with qPCR/dPCR/ddPCR
- Good working knowledge of Genious and/or CLC Main workbench
- Familiarity with off-target analysis (e.g., GUIDE-seq) and experience with immune cells or viral vectors a plus but not required
- Exceptional teamwork and communication skills
- Flexibility to pivot from plan A to plan B and ability to synthesize complex information and focus on key deliverables
About us: GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. We are focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics. Our corporate operations are in both Cambridge, MA and Seattle, WA.
We are building an exceptional company culture focused on empowerment, care for one another, an appreciation for diversity and inclusion, and the development of our people. We are looking for people who are not only incredible experts in their field, but also individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so.
EEO Statement: GentiBio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & staffing agencies: GentiBio does not accept agency resumes unless contacted directly by internal GentiBio Talent Acquisition. Please do not forward resumes to careers@gentibio.com, GentiBio employees or any other company location; GentiBio is not responsible for any fees related to unsolicited resumes.
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