Postdoctoral Research Associate - Bone Marrow Transplant & Cell Therapy
Job description
POSTDOCTORAL POSITION to study the function of novel CAR T cell-based therapies for pediatric brain tumors
- Designing, generating, and optimizing chimeric antigen receptors (CARs) specific for pediatric brain tumors.
- Enhancing CAR T cell effector function and longevity using different genetic manipulations
- Studying brain tumor microenvironment and its effect on CAR T cell function
Haydar D, Houke H, Chiang J, Yi Z, Odé Z, Caldwell K, Zhu X, Mercer KS, Stripay JL, Shaw TI, Vogel P, DeRenzo C, Baker SJ, Roussel MF, Gottschalk S, Krenciute G. Cell surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery. Neuro Oncol. 2020
Prinzing B, Schreiner P, Bell M, Fan Y, Krenciute G*, Gottschalk S*. MyD88/CD40 signaling retains CAR T cells in a less differentiated state. JCI Insight. 2020. *co-senior authors
Odé Z, Condori J, Peterson N, Zhou S, Krenciute G. CRISPR-Mediated Non-Viral Site-Specific Gene Integration and Expression in T Cells: Protocol and Application for T-Cell Therapy. Cancers (Basel). 2020
Yi Z, Brooke LP, Cao F, Gottschalk S, Krenciute G. Optimizing EphA2-CAR T cells for the Adoptive Immunotherapy of Glioma. Molecular Therapy - Methods & Clinical Development. 2018
Krenciute G, Prinzing BL, Yi Z, Wu MF, Liu H, Dotti G, Balyasnikova IV, Gottschalk S. Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen-loss variants. Cancer Immunol Res. 2017
Interested applicants should send their CV, a cover letter describing research experience and interests, and names and email addresses of three references to: giedre.krenciute@stjude.org
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