Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Summary:

This position will focus on the implementation of biological assays to support the development and characterization of SeaGEN antibodies and antibody-drug conjugates (ADCs). The successful candidate will work closely with various functional areas within Process Sciences, Manufacturing and Quality Control. The successful candidate will develop, qualify and implement potency assays to support process development activities, drug product release and regulatory filings.

Principal Responsibilities:

• Use cell line engineering technology to develop, implement, and transfer potency assays to QC GMP group (cytotoxicity, binding, signaling assay, Fc effector function, and immunological assays) to support early- and late-phase product and process development
• Identification and implementation of new technologies and approaches
• Drafting of potency assay method standard operating procedures (SOPs), technical reports and data summaries
• Organize and present data at group and department meetings
• Represent Potency Assays group on project and departmental initiative teams
• Supervise and mentor research associate(s)

Required Qualifications:

• PhD in Immunology, Molecular Biology, Cancer Biology, Biochemistry, Bioengineering or related discipline. MS and BS with equivalent work experience will be considered
• Experience in cell line engineering using technology such as viral construction and gene editing
• Experience in developing in vitro or ex vivo cell-based bioassays and immunoassays
• Excellent oral and written communication skills
• Candidate must be driven, highly motivated and be able to work in a fast-paced, matrixed environment
• Strong interpersonal skills and the ability to work in a multi-disciplinary team environment
• Creative, independent, well-organized, and solution-oriented

Preferred Qualifications:

• Scientist: 0-3 years of relevant experience
  • For MS: 9-12 years & BS: 14-17 years
• Sr. Scientist: 3-5 years of relevant experience, industrial and CMC experience preferred
  • For MS: 12-14 years & BS: 17-19 years
• Preferred skills include immunology-related knowledge and experience including Fc effector function and adaptive T and B cell biology
• Demonstrated technical expertise in immunological and general cell-based assays, ELISAs, homogeneous binding assays (e.g.AlphaLISA and TR-FRET assays), Octet, FACS, tissue culture and molecular biology techniques
• Experience in the use of live cell imaging systems and high-throughput liquid-handling systems is a plus

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.

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