Scientist, Modeling and Simulation

Scientist, Pharmacometrics

Overview

Alnylam (Nasdaq: ALNY) is delivering on a bold vision to turn scientific possibility into reality, with a robust RNA interference (RNAi) therapeutics platform. As the pioneer in RNAi and the leading RNAi therapeutics company, we have always been uncompromisingly dedicated to translating the breakthrough science into transformational medicines to help as many people as possible. Long focused on rare and genetic diseases, our scientific advances are now allowing us to bring the power of RNAi therapeutics to more prevalent diseases and as a result, we are beginning to recognize the full potential of this new class of medicines.

Alnylam is committed to its journey to become a top 5 independent, global biopharma company. We are already admired and recognized for our dedication to patients, company culture that empowers people to do their best work, track record of scientific innovation, social responsibility, and commercial excellence.

Founded in 2002, and headquartered in Cambridge, Mass., Alnylam has over 1,650 employees at work across the globe. We are seeking smart, passionate, “change the world” kind of people who are ready to say, “challenge accepted” to our mission. Thanks to the commitment of every employee globally, Alnylam is proud to have been recognized as one of Fast Company’s 2021 Best Workplaces for Innovators, a Science Magazine Top Employer three years in a row (2019-2021), a Boston Globe Top Places to Work seven years in a row (2015-2021), a Great Place to Work in Asia, Brazil, the U.K., and Switzerland, Searmount’s 100 Best Companies and Best Companies for Dads, Bloomberg’s Gender Equality Index, among others.

Summary of Key Responsibilities

• With guidance, plan, analyze, and report population pharmacokinetic/pharmacodynamic, exposure-response, and disease progression models.
• Apply simulation methods to support dose selection, trial design, and Go/No-Go decisions.
• As appropriate, effectively partner with clinical, biostatistics, DMPK, and regulatory departments.
• Participate in the preparation of reports/abstracts/manuscripts for publications and regulatory documents.

Qualifications

• Pharm D, or Ph.D. degree in pharmaceutics, pharmacokinetics, pharmacometrics, biostatistics, engineering disciples, and related quantitative fields.
• 0-3 years of post-doctoral experience in academia, pharmaceutical industry or regulatory agency.
• Experience representing application of pharmacometrics in drug development and hands-on modeling experience.

Special Skills/Abilities:

• Required skills:
  • Strong proficiency in R programming, and in non-linear mixed effects modeling software like NONMEM, Monolix, Phoenix, or similar.
  • Good understanding of pharmacokinetic/pharmacodynamic principles and drug development
  • Strong written and oral communication skills and interpersonal skills.
• Desirable skills:
  • Familiarity with hierarchical modeling of longitudinal continuous and non-continuous data.
  • Familiarity with application of Bayesian methods.
  • Application and development of system pharmacology models.

Supervision: Motivated and collaborative individual who can function independently with minimal supervision. Candidate should be able to multi-task and prioritize to provide pharmacometric support to help advance portfolio. Travel may occasionally be required.