About Voyager

Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging innovative expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager’s TRACER AAV capsid discovery platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis and Neurocrine Biosciences as well as multiple programs in Voyager’s own pipeline. Voyager’s pipeline includes preclinical programs in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS), each with validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit www.voyagertherapeutics.com

Research Associate / Senior Research Associate – Histology

Reporting to the Senior Scientist, the RA/S.RA will contribute to Voyager’s research team at its facility in Cambridge, Massachusetts. This is a hands-on position for a person committed to helping the broader team conduct innovative drug discovery research in a collaborative environment. We are seeking a person who is enthusiastic about biomedical research and can work in close partnership with other scientists and team members. This is an ideal position for an individual strong experience in histological techniques such as tissue grossing, processing, embedding, sectioning, special staining and immunohistochemistry/immunofluoroscence of fresh frozen and formalin fixed paraffin embedded rodents and primate tissues. The successful candidate should thrive in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

Responsibilities:

• Prepare animal specimens for routine histology procedures, including handling unfixed and fixed primate and rodent tissues and organs, tissue trimming and processing, embedding, and sectioning, H&E and special stains such as LFB, silver staining as needed.
• Archive histological specimens across multiple programs that includes fixed tissues, paraffin and frozen tissue blocks, unstained and stained slides.
• Perform routine histology instrument operations with working knowledge of maintenance and troubleshooting.
• Assist in developing and performing novel tissue-based staining methodologies such as immunohistochemistry (IHC), immunofluorescence (IF), and in-situ hybridization (ISH) assay development.
• Subsequent image acquisition of the stained tissues whole slide scanners such as Olympus VS 200 or Aperio Versa, epifluorescence and confocal microscopy.
• Coordinate the workflow in histology to meet project and company goals.
• Execute and troubleshoot standard protocols, adapt new protocols into practice

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Preferred:

• Basic knowledge of neuroanatomy and neuroscience.
• Existing experience in hospital/clinical or pharmaceutical/ biotechnology industry.
• Experience in cross-functional therapeutic program team.
• Experience within a hospital or start-up or small biotech environment.
• Experience with automated stainer (Ventana Discovery Ultra or Leica BondRx), whole slide scanner (Aperio Versa), would be a strong plus.

Requirements:

• S. in Biology or related field.
• A minimum of 3-7 years of hands-on experience with excellent tissue handling and histological techniques.
• Self-motivated, able to work collaboratively, highly organized with strong attention to detail.